General Information

  • ID:  hor004092
  • Uniprot ID:  P85867
  • Protein name:  Pyrokinin
  • Gene name:  NA
  • Organism:  Locusta migratoria (Migratory locust)
  • Family:  Pyrokinin family
  • Source:  Animal
  • Expression:  Found in the abdominal ganglia and perisympathetic organs. Not detected in the thoracic ganglia, subesophageal ganglion, corpora cardiaca, corpora allata, hypocerebral ganglion or frontal ganglion.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Locusta (genus), Oedipodinae (subfamily), Acrididae (family), Acridoidea (superfamily), Acridomorpha, Acrididea (infraorder), Caelifera (suborder), Orthoptera (order), Polyneoptera (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  DGGEPAAPLWFGPRV
  • Length:  15(1-15)
  • Propeptide:  DGGEPAAPLWFGPRV
  • Signal peptide:  NA
  • Modification:  T15 Valine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Myoactive
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor004092_AF2.pdbhor004092_ESM.pdb

Physical Information

Mass: 181865 Formula: C73H105N19O20
Absent amino acids: CHIKMNQSTY Common amino acids: GP
pI: 4.18 Basic residues: 1
Polar residues: 3 Hydrophobic residues: 6
Hydrophobicity: -26.67 Boman Index: -974
Half-Life: 1.1 hour Half-Life Yeast: 3 min
Half-Life E.Coli: >10 hour Aliphatic Index 58.67
Instability Index: 6181.33 Extinction Coefficient cystines: 5500
Absorbance 280nm: 392.86

Literature

  • PubMed ID:  12504101
  • Title:  Mass Spectrometric Analysis of the Perisympathetic Organs in Locusts: Identification of Novel Periviscerokinins